View source for 3wdk


==Crystal structure of 4-phosphopantoate-beta-alanine ligase complexed with reaction intermediate==
<StructureSection load='3wdk' size='340' side='right'caption='[[3wdk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wdk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WDK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PTJ:5-O-[(S)-HYDROXY{[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]OXY}PHOSPHORYL]ADENOSINE'>PTJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wdk OCA], [https://pdbe.org/3wdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wdk RCSB], [https://www.ebi.ac.uk/pdbsum/3wdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wdk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPS_THEKO PPS_THEKO] Catalyzes the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Atomi H]]
[[Category: Imanaka T]]
[[Category: Ishibashi T]]
[[Category: Kishimoto A]]
[[Category: Kita A]]
[[Category: Miki K]]
[[Category: Tomita H]]
[[Category: Yokooji Y]]