View source for 3wle


==Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with NAD==
<StructureSection load='3wle' size='340' side='right'caption='[[3wle]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wle]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WLE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.164&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wle OCA], [https://pdbe.org/3wle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wle RCSB], [https://www.ebi.ac.uk/pdbsum/3wle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wle ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A1X808_CANPA A1X808_CANPA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structure-guided design of substrate-binding pocket inversed the stereoselectivity of an NADH-dependent medium-chain alcohol dehydrogenase (MDR) from Prelog to anti-Prelog. The pocket-forming amino acids, especially the unconserved residues as hotspots, play critical roles in directing MDRs' stereoselectivity.

Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase.,Wang S, Nie Y, Xu Y, Zhang R, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R Chem Commun (Camb). 2014 Jun 24;50(58):7770-2. doi: 10.1039/c4cc01752h. PMID:24834985<ref>PMID:24834985</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3wle" style="background-color:#fffaf0;"></div>

==See Also==
*[[Carbonyl reductase 3D structures|Carbonyl reductase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candida parapsilosis]]
[[Category: Large Structures]]
[[Category: Chan HC]]
[[Category: Guo RT]]
[[Category: Huang CH]]
[[Category: Nie Y]]
[[Category: Wang SS]]
[[Category: Xiao R]]
[[Category: Xu Y]]
[[Category: Zhang RZ]]