View source for 3wlu


==Crystal Structure of human galectin-9 NCRD with Selenolactose==
<StructureSection load='3wlu' size='340' side='right'caption='[[3wlu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wlu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WLU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LSE:2-(TRIMETHYLSILYL)ETHYL+4-O-BETA-D-GALACTOPYRANOSYL-6-SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wlu OCA], [https://pdbe.org/3wlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wlu RCSB], [https://www.ebi.ac.uk/pdbsum/3wlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wlu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref> 

==See Also==
*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ando H]]
[[Category: Ishida H]]
[[Category: Kato R]]
[[Category: Kiso M]]
[[Category: Makyio H]]
[[Category: Suzuki T]]
[[Category: Wakatsuki S]]
[[Category: Yamada Y]]