View source for 3wmi


==Crystal structure of EIAV wild type gp45==
<StructureSection load='3wmi' size='340' side='right'caption='[[3wmi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wmi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WMI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wmi OCA], [https://pdbe.org/3wmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wmi RCSB], [https://www.ebi.ac.uk/pdbsum/3wmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wmi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E2E2L9_9RETR E2E2L9_9RETR] The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.[ARBA:ARBA00025621]  The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.[ARBA:ARBA00024648]
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</StructureSection>
[[Category: Equus caballus]]
[[Category: Large Structures]]
[[Category: Du J]]
[[Category: Liu X]]
[[Category: Qiao W]]