View source for 3wry


==Crystal structure of helicase complex 2==
<StructureSection load='3wry' size='340' side='right'caption='[[3wry]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wry]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Solanum_lycopersicum Solanum lycopersicum] and [https://en.wikipedia.org/wiki/Tobacco_mosaic_virus_strain_tomato/L Tobacco mosaic virus strain tomato/L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wry OCA], [https://pdbe.org/3wry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wry RCSB], [https://www.ebi.ac.uk/pdbsum/3wry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wry ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TM1R_SOLLC TM1R_SOLLC] Inhibitor of viral RNA replication which confers resistance to some tobamoviruses including tomato mosaic virus (ToMV) (e.g. isolate L), tobacco mosaic virus (TMV), tobacco mild green mosaic virus (TMGMV) and pepper mild mottle virus (PMMoV), but not to resistance-breaking isolates of ToMV (e.g. LT1, SL-1 and ToMV1-2) and tomato brown rugose fruit virus (ToBRFV) (PubMed:17699618, PubMed:3686829, PubMed:17238011, PubMed:19423673, PubMed:23415925, PubMed:29582165, PubMed:28107419). Prevents tobamoviruses RNA replication by affecting the association of tobamoviruses replication proteins (large and small subunits) with host membrane-associated proteins (e.g. TOM1, TOM2A and ARL8), thus inhibiting the replication complex formation on the membranes and avoiding viral negative-strand RNA synthesis (PubMed:17699618, PubMed:19423673, PubMed:23658455, PubMed:23415925). Inhibits triphosphatase activity of ToMV replication proteins (PubMed:25092327).<ref>PMID:17238011</ref> <ref>PMID:17699618</ref> <ref>PMID:19423673</ref> <ref>PMID:23415925</ref> <ref>PMID:23658455</ref> <ref>PMID:25092327</ref> <ref>PMID:28107419</ref> <ref>PMID:29582165</ref> <ref>PMID:3686829</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Solanum lycopersicum]]
[[Category: Tobacco mosaic virus strain tomato/L]]
[[Category: Katoh E]]
[[Category: Matsumura H]]