View source for 3wvf


==Crystal structure of YidC from Escherichia coli==
<StructureSection load='3wvf' size='340' side='right'caption='[[3wvf]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wvf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvf OCA], [https://pdbe.org/3wvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvf RCSB], [https://www.ebi.ac.uk/pdbsum/3wvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YIDC_ECOUT YIDC_ECOUT] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, the transmembrane and periplasmic regions of YidC interact with the Sec proteins, forming a multi-protein complex for Sec-dependent membrane protein integration. Here, we report the crystal structure of full-length Escherichia coli YidC. The structure reveals that a hydrophilic groove, formed by five transmembrane helices, is a conserved structural feature of YidC, as compared to the previous YidC structure from Bacillus halodurans, which lacks a periplasmic domain. Structural mapping of the substrate- or Sec protein-contact sites suggested the importance of the groove for the YidC functions as a chaperone and an insertase, and provided structural insight into the multi-protein complex.

Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase.,Kumazaki K, Kishimoto T, Furukawa A, Mori H, Tanaka Y, Dohmae N, Ishitani R, Tsukazaki T, Nureki O Sci Rep. 2014 Dec 3;4:7299. doi: 10.1038/srep07299. PMID:25466392<ref>PMID:25466392</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3wvf" style="background-color:#fffaf0;"></div>

==See Also==
*[[Insertase|Insertase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli UTI89]]
[[Category: Large Structures]]
[[Category: Ishitani R]]
[[Category: Kishimoto T]]
[[Category: Kumazaki K]]
[[Category: Nureki O]]
[[Category: Tsukazaki T]]