View source for 3wvz


==Crystal structure of Hikeshi, a new nuclear transport receptor of Hsp70==
<StructureSection load='3wvz' size='340' side='right'caption='[[3wvz]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wvz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvz OCA], [https://pdbe.org/3wvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvz RCSB], [https://www.ebi.ac.uk/pdbsum/3wvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIKES_HUMAN HIKES_HUMAN] Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.<ref>PMID:22541429</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Choi S]]
[[Category: Hong RH]]
[[Category: Imamoto N]]
[[Category: Kose S]]
[[Category: Lee SJ]]
[[Category: Park IY]]
[[Category: Son SY]]
[[Category: Song J]]
[[Category: Watanabe A]]
[[Category: Yamashita E]]