View source for 3wye


==Crystal Structure of chimeric engineered (2S,3S)-butanediol dehydrogenase complexed with NAD+==
<StructureSection load='3wye' size='340' side='right'caption='[[3wye]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3wye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum] and [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wye OCA], [https://pdbe.org/3wye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wye RCSB], [https://www.ebi.ac.uk/pdbsum/3wye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wye ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BUDC_CORGT BUDC_CORGT] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1]<ref>PMID:11577733</ref> [https://www.uniprot.org/uniprot/BUDC_KLEPN BUDC_KLEPN] Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH.
== References ==
<references/>
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</StructureSection>
[[Category: Corynebacterium glutamicum]]
[[Category: Klebsiella pneumoniae]]
[[Category: Large Structures]]
[[Category: Kusunoki M]]
[[Category: Oyama T]]
[[Category: Shimegi T]]
[[Category: Ui S]]