View source for 3ztl


==Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni==
<StructureSection load='3ztl' size='340' side='right'caption='[[3ztl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ztl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZTL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ztl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztl OCA], [https://pdbe.org/3ztl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ztl RCSB], [https://www.ebi.ac.uk/pdbsum/3ztl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O97161_SCHMA O97161_SCHMA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
2-Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP-independent chaperones upon exposure to high peroxide concentrations. These alternative functions have been associated with changes in the oligomerization state from low-(LMW) to high-molecular-weight (HMW) species. Here we present the structures of Schistosoma mansoni PrxI in both states: the LMW decamer and the HMW 20-mer formed by two stacked decamers. The latter is the structure of a 2-Cys Prx chaperonic form. Comparison of the structures sheds light on the mechanism by which chemical stressors, such as high H(2)O(2) concentration and acidic pH, are sensed and translated into a functional switch in this protein family. We also propose a model to account for the in vivo formation of long filaments of stacked Prx rings.

Moonlighting by different stressors: crystal structure of the chaperone species of a 2-cys peroxiredoxin.,Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F Structure. 2012 Mar 7;20(3):429-39. PMID:22405002<ref>PMID:22405002</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ztl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Angelucci F]]
[[Category: Bellelli A]]
[[Category: Boumis G]]
[[Category: Brunori M]]
[[Category: Miele AE]]
[[Category: Saccoccia F]]