View source for 3zxf


==High resolution structure of Human Galectin-7==
<StructureSection load='3zxf' size='340' side='right'caption='[[3zxf]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zxf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxf OCA], [https://pdbe.org/3zxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxf RCSB], [https://www.ebi.ac.uk/pdbsum/3zxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7) in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth. Producing ligands able to selectively target hGal-7 will offer promising tools for deciphering cancer processes in which hGal-7 is involved as well as present potential solutions for future therapeutics. Here we report the high resolution crystal structure of hGal-7 in complex with a synthetic 2-O-benzylphosphate-galactoside inhibitor (which is &gt;60-fold potent than its parent galactoside). The high resolution crystallographic analysis highlights the validity of using saccharide derivatives, conserving properties of the galactose binding, while enhanced affinity and specificity is provided by the added phosphate group. This structural information will allow the design of further inhibitor with improved potency and specificity. Structured digital abstract hGal-7 and hGal-7 bind by x-ray crystallography (View interaction).

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.,Masuyer G, Jabeen T, Oberg CT, Leffler H, Nilsson UJ, Acharya KR FEBS J. 2011 Nov 7. doi: 10.1111/j.1742-4658.2011.08414.x. PMID:22059385<ref>PMID:22059385</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zxf" style="background-color:#fffaf0;"></div>

==See Also==
*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acharya KR]]
[[Category: Leffler H]]
[[Category: Masuyer G]]
[[Category: Nilsson UJ]]
[[Category: Oberg CT]]