View source for 3zxy


==Structure of S218A mutant of the protease domain of PatA==
<StructureSection load='3zxy' size='340' side='right'caption='[[3zxy]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxy OCA], [https://pdbe.org/3zxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxy RCSB], [https://www.ebi.ac.uk/pdbsum/3zxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q52QI9_PRODI Q52QI9_PRODI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cyanobactins, including patellamides, are a group of cyanobacterial post-translationally modified ribosomal cyclic peptides. The final product should in theory be predictable from the sequence of the precursor peptide and the associated tailoring enzymes. Understanding the mechanism and recognition requirements of these enzymes will allow their rational engineering. We have identified three new cyanobactins from a Cyanothece PCC 7425 culture subjected to a heat shock. One of these compounds revealed a novel signature signal for ThcA, the subtilisin-like serine protease that is homologous to the patellamide protease PatA. The crystal structure of the latter and modelling studies allow rationalisation of the recognition determinants for both enzymes, consistent with the ribosomal biosynthetic origin of the new compounds.

The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides.,Houssen WE, Koehnke J, Zollman D, Vendome J, Raab A, Smith MC, Naismith JH, Jaspars M Chembiochem. 2012 Nov 21. doi: 10.1002/cbic.201200661. PMID:23169461<ref>PMID:23169461</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zxy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Prochloron didemni]]
[[Category: Houssen WE]]
[[Category: Jaspars M]]
[[Category: Koehnke J]]
[[Category: Naismith JH]]
[[Category: Raab A]]
[[Category: Smith MC]]
[[Category: Vendome J]]
[[Category: Zollman D]]