View source for 3zyw


==Crystal structure of the first glutaredoxin domain of human glutaredoxin 3 (GLRX3)==
<StructureSection load='3zyw' size='340' side='right'caption='[[3zyw]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyw OCA], [https://pdbe.org/3zyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyw RCSB], [https://www.ebi.ac.uk/pdbsum/3zyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX3_HUMAN GLRX3_HUMAN] Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Cocking R]]
[[Category: Edwards A]]
[[Category: Johansson C]]
[[Category: Kavanagh KL]]
[[Category: Krojer T]]
[[Category: Muniz JRC]]
[[Category: Oppermann U]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]