View source for 4acj


==Crystal structure of the TLDC domain of Oxidation resistance protein 2 from zebrafish==
<StructureSection load='4acj' size='340' side='right'caption='[[4acj]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4acj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acj OCA], [https://pdbe.org/4acj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acj RCSB], [https://www.ebi.ac.uk/pdbsum/4acj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A9JTH8_DANRE A9JTH8_DANRE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97A) and adopts an overall globular shape. Two antiparallel beta-sheets form a central beta-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures. Proteins 2012. (c) 2012 Wiley Periodicals, Inc.

Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish.,Blaise M, Alsarraf HM, Wong JE, Midtgaard SR, Laroche F, Schack L, Spaink H, Stougaard J, Thirup S Proteins. 2012 Jun;80(6):1694-8. doi: 10.1002/prot.24050. Epub 2012 Mar 20. PMID:22434723<ref>PMID:22434723</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4acj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: B Alsarraf HMA]]
[[Category: Blaise M]]
[[Category: Laroche F]]
[[Category: Midtgaard SR]]
[[Category: Schack L]]
[[Category: Spaink H]]
[[Category: Stougaard J]]
[[Category: Thirup S]]
[[Category: Wong JEMM]]