View source for 4atq


==GABA-transaminase A1R958 in complex with external aldimine PLP-GABA adduct==
<StructureSection load='4atq' size='340' side='right'caption='[[4atq]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4atq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_aurescens_TC1 Paenarthrobacter aurescens TC1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ATQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4atq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atq OCA], [https://pdbe.org/4atq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4atq RCSB], [https://www.ebi.ac.uk/pdbsum/4atq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4atq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A1R958_PAEAT A1R958_PAEAT] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Two complex structures of the gamma-aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 A, features the internal aldimine formed by reaction between the -amino group of Lys295 and the cofactor pyridoxal phosphate (PLP); the second, determined to a resolution of 2.75 A, features the external aldimine adduct formed between PLP and GABA in the first half-reaction. This is the first structure of a microbial GABA transaminase in complex with its natural external aldimine and reveals the molecular determinants of GABA binding in this enzyme.

Structures of a gamma-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct.,Bruce H, Nguyen Tuan A, Mangas Sanchez J, Leese C, Hopwood J, Hyde R, Hart S, Turkenburg JP, Grogan G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1175-80., doi: 10.1107/S1744309112030023. Epub 2012 Sep 29. PMID:23027742<ref>PMID:23027742</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4atq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Paenarthrobacter aurescens TC1]]
[[Category: Bruce H]]
[[Category: Grogan G]]
[[Category: Hart S]]
[[Category: Mangas Sanchez J]]
[[Category: Tuan AN]]
[[Category: Turkenburg JP]]