View source for 4ayw


==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)==
<StructureSection load='4ayw' size='340' side='right'caption='[[4ayw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ayw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4aa3 4aa3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayw OCA], [https://pdbe.org/4ayw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayw RCSB], [https://www.ebi.ac.uk/pdbsum/4ayw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress. ABCB10 is therefore a potential therapeutic target for diseases in which increased mitochondrial reactive oxygen species production and oxidative stress play a major role. The crystal structure of apo-ABCB10 shows a classic exporter fold ABC transporter structure, in an open-inwards conformation, ready to bind the substrate or nucleotide from the inner mitochondrial matrix or membrane. Unexpectedly, however, ABCB10 adopts an open-inwards conformation when complexed with nonhydrolysable ATP analogs, in contrast to other transporter structures which adopt an open-outwards conformation in complex with ATP. The three complexes of ABCB10/ATP analogs reported here showed varying degrees of opening of the transport substrate binding site, indicating that in this conformation there is some flexibility between the two halves of the protein. These structures suggest that the observed plasticity, together with a portal between two helices in the transmembrane region of ABCB10, assist transport substrate entry into the substrate binding cavity. These structures indicate that ABC transporters may exist in an open-inwards conformation when nucleotide is bound. We discuss ways in which this observation can be aligned with the current views on mechanisms of ABC transporters.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.,Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi:, 10.1073/pnas.1217042110. Epub 2013 May 28. PMID:23716676<ref>PMID:23716676</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ayw" style="background-color:#fffaf0;"></div>

==See Also==
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Barr AJ]]
[[Category: Berridge G]]
[[Category: Bountra C]]
[[Category: Bray JE]]
[[Category: Bullock AN]]
[[Category: Burgess-Brown N]]
[[Category: Carpenter EP]]
[[Category: Chaikuad A]]
[[Category: Chalk R]]
[[Category: Das S]]
[[Category: Dong L]]
[[Category: Dong Y]]
[[Category: Edwards AM]]
[[Category: Gileadi O]]
[[Category: Goubin S]]
[[Category: Kim J]]
[[Category: Krojer T]]
[[Category: Li Q]]
[[Category: Mahajan P]]
[[Category: Mukhopadhyay S]]
[[Category: Muniz JRC]]
[[Category: Pike ACW]]
[[Category: Quigley A]]
[[Category: Shintre CA]]
[[Category: Shrestha L]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Xia X]]
[[Category: Yang J]]
[[Category: Von Delft F]]