View source for 4bja


==Globin-like protein Glb-12 from C.elegans==
<StructureSection load='4bja' size='340' side='right'caption='[[4bja]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bja OCA], [https://pdbe.org/4bja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bja RCSB], [https://www.ebi.ac.uk/pdbsum/4bja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bja ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q09514_CAEEL Q09514_CAEEL] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Moderate levels of reactive oxygen species (ROS) are now recognized as redox signalling molecules. However, thus far, only mitochondria and NADPH oxidases have been identified as cellular sources of ROS in signalling. Here we identify a globin (GLB-12) that produces superoxide, a type of ROS, which serves as an essential signal for reproduction in C. elegans. We find that GLB-12 has an important role in the regulation of multiple aspects in germline development, including germ cell apoptosis. We further describe how GLB-12 displays specific molecular, biochemical and structural properties that allow this globin to act as a superoxide generator. In addition, both an intra- and extracellular superoxide dismutase act as key partners of GLB-12 to create a transmembrane redox signal. Our results show that a globin can function as a driving factor in redox signalling, and how this signal is regulated at the subcellular level by multiple control layers.

A redox signalling globin is essential for reproduction in Caenorhabditis elegans.,De Henau S, Tilleman L, Vangheel M, Luyckx E, Trashin S, Pauwels M, Germani F, Vlaeminck C, Vanfleteren JR, Bert W, Pesce A, Nardini M, Bolognesi M, De Wael K, Moens L, Dewilde S, Braeckman BP Nat Commun. 2015 Dec 1;6:8782. doi: 10.1038/ncomms9782. PMID:26621324<ref>PMID:26621324</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4bja" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Bert W]]
[[Category: Bolognesi M]]
[[Category: Braeckman BP]]
[[Category: De Henau S]]
[[Category: De Wael K]]
[[Category: Dewilde S]]
[[Category: Germani F]]
[[Category: Moens L]]
[[Category: Nardini M]]
[[Category: Pauwels M]]
[[Category: Pesce A]]
[[Category: Tilleman L]]
[[Category: Vanfleteren JR]]
[[Category: Vlaeminck C]]