View source for 4bjs


==Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae==
<StructureSection load='4bjs' size='340' side='right'caption='[[4bjs]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bjs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjs OCA], [https://pdbe.org/4bjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjs RCSB], [https://www.ebi.ac.uk/pdbsum/4bjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIF1_YEAST RIF1_YEAST] Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.<ref>PMID:1577274</ref> <ref>PMID:7867933</ref> <ref>PMID:9087429</ref> <ref>PMID:10531008</ref> <ref>PMID:15572688</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Bunker RD]]
[[Category: Gut H]]
[[Category: Scrima A]]
[[Category: Shi T]]
[[Category: Thoma NH]]