View source for 4bwr


==Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold==
<StructureSection load='4bwr' size='340' side='right'caption='[[4bwr]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xm6 2xm6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwr OCA], [https://pdbe.org/4bwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwr RCSB], [https://www.ebi.ac.uk/pdbsum/4bwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwr ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/ESIB_ECOL6 ESIB_ECOL6]] Upon host (human neutrophil) infection interferes with productive FCAR signaling, inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils, decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils, all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils, but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins, including phospholipase C-gamma and MAP kinases, all actions that may be advantageous to the pathogen.<ref>PMID:23882011</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia coli CFT073]]
[[Category: Large Structures]]
[[Category: Cartocci E]]
[[Category: Costenaro L]]
[[Category: Daura X]]
[[Category: Ferrer-Navarro M]]
[[Category: Leonchiks A]]
[[Category: Marechal J-D]]
[[Category: Pastorello I]]
[[Category: Reverter D]]
[[Category: Serino L]]
[[Category: Soriani M]]
[[Category: Urosev D]]
[[Category: Zhulenkovs D]]