View source for 4cct


==Dengue 1 cryo-EM reconstruction==
<SX load='4cct' size='340' side='right' viewer='molstar' caption='[[4cct]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cct]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4azx 4azx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CCT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cct OCA], [https://pdbe.org/4cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cct RCSB], [https://www.ebi.ac.uk/pdbsum/4cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cct ProSAT]</span></td></tr>
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== Function ==
[https://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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== Publication Abstract from PubMed ==
Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-A resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.

Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.,Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416<ref>PMID:23637416</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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[[Category: Dengue virus 1]]
[[Category: Large Structures]]
[[Category: Kostyuchenko VA]]
[[Category: Lok SM]]
[[Category: Ng TS]]
[[Category: Tan JL]]
[[Category: Zhang Q]]