View source for 4cge


==Crystal structure of Mycobacterium tuberculosis Resuscitation promoting factor E==
<StructureSection load='4cge' size='340' side='right'caption='[[4cge]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cge]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CGE FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cge OCA], [https://pdbe.org/4cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cge RCSB], [https://www.ebi.ac.uk/pdbsum/4cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cge ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/RPFE_MYCTU RPFE_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref>   Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Alber T]]
[[Category: Mavrici D]]
[[Category: Prigozhin DM]]