View source for 4cyn


==Leishmania major N-myristoyltransferase in complex with an aminoacylpyrrolidine inhibitor (2b)==
<StructureSection load='4cyn' size='340' side='right'caption='[[4cyn]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A6M:(3R)-3-AMINO-4-(4-CHLOROPHENYL)-1-[(3R,4S)-3-(4-CHLOROPHENYL)-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]BUTAN-1-ONE'>A6M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyn OCA], [https://pdbe.org/4cyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyn RCSB], [https://www.ebi.ac.uk/pdbsum/4cyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Inhibitors of Leishmania NMT, a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained and the active diastereoisomer of one of the inhibitors was identified. Based on structural insights, enzyme inhibition was increased 40-fold through hybridization of two distinct binding modes, resulting in novel, highly potent Leishmania donovani NMT inhibitors with good selectivity over the human enzyme.

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors.,Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW J Med Chem. 2014 Sep 19. PMID:25238611<ref>PMID:25238611</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4cyn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Leishmania major]]
[[Category: Bell AS]]
[[Category: Brannigan JA]]
[[Category: Goncalves V]]
[[Category: Hutton JA]]
[[Category: Leatherbarrow RJ]]
[[Category: Paape D]]
[[Category: Roberts SM]]
[[Category: Smith DF]]
[[Category: Tate EW]]
[[Category: Waugh T]]
[[Category: Wilkinson AJ]]