View source for 4dfu


==Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin==
<StructureSection load='4dfu' size='340' side='right'caption='[[4dfu]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4dfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vcq 3vcq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r82 3r82]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=QUE:3,5,7,3,4-PENTAHYDROXYFLAVONE'>QUE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfu OCA], [https://pdbe.org/4dfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfu RCSB], [https://www.ebi.ac.uk/pdbsum/4dfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA] 

==See Also==
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Enterococcus casseliflavus]]
[[Category: Large Structures]]
[[Category: Anderson WF]]
[[Category: Di Leo R]]
[[Category: Dong A]]
[[Category: Egorova E]]
[[Category: Evdokimova E]]
[[Category: Li H]]
[[Category: Minasov G]]
[[Category: Savchenko A]]
[[Category: Shakya T]]
[[Category: Stogios PJ]]
[[Category: Wright GD]]