View source for 4dji


==Structure of glutamate-GABA antiporter GadC==
<StructureSection load='4dji' size='340' side='right'caption='[[4dji]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4dji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DJI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.187&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dji OCA], [https://pdbe.org/4dji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dji RCSB], [https://www.ebi.ac.uk/pdbsum/4dji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dji ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GADC_ECOLI GADC_ECOLI] Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Fan C]]
[[Category: Lu PL]]
[[Category: Ma D]]
[[Category: Shi YG]]
[[Category: Wang JW]]
[[Category: Yan CY]]
[[Category: Yin P]]