View source for 4dq1


==Thymidylate synthase from Staphylococcus aureus.==
<StructureSection load='4dq1' size='340' side='right'caption='[[4dq1]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4dq1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DQ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq1 OCA], [https://pdbe.org/4dq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dq1 RCSB], [https://www.ebi.ac.uk/pdbsum/4dq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_STAAM TYSY_STAAM] Provides the sole de novo source of dTMP for DNA biosynthesis.[HAMAP-Rule:MF_00008]

==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus Mu50]]
[[Category: Baker D]]
[[Category: Guinn K]]
[[Category: Holowicki J]]
[[Category: Ioerger T]]
[[Category: Jedrzejczak R]]
[[Category: Joachimiak A]]
[[Category: Osipiuk J]]
[[Category: Rubin E]]
[[Category: Sacchettini J]]