View source for 4eje


==Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide==
<StructureSection load='4eje' size='340' side='right'caption='[[4eje]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eje]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eje OCA], [https://pdbe.org/4eje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eje RCSB], [https://www.ebi.ac.uk/pdbsum/4eje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eje ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> 

==See Also==
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ebola virus - Mayinga, Zaire, 1976]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Camara-Artigas A]]