View source for 4el6


==Crystal structure of IPSE/alpha-1 from Schistosoma mansoni eggs==
<StructureSection load='4el6' size='340' side='right'caption='[[4el6]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4el6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EL6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4el6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4el6 OCA], [https://pdbe.org/4el6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4el6 RCSB], [https://www.ebi.ac.uk/pdbsum/4el6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4el6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q869D4_SCHMA Q869D4_SCHMA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1) triggers the release of large amounts of interleukin-4 from human blood basophils, thus presumably playing an immunomodulatory role during schistosome infection. IPSE/alpha-1 was crystallized and a native X-ray data set was collected to 1.66 A resolution from a single crystal at 100 K using synchrotron radiation. The crystal belonged to space group P6(1) or P6(5), with one molecule per asymmetric unit.

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1).,Mayerhofer H, Schramm G, Hatzopoulos GN, Mueller-Dieckmann C, Haas H, Mueller-Dieckmann J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):594-6. doi:, 10.1107/S1744309109015899. Epub 2009 May 22. PMID:019478439<ref>PMID:019478439</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4el6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Bade S]]
[[Category: Barths D]]
[[Category: Blindow S]]
[[Category: Frey A]]
[[Category: Haas H]]
[[Category: Madl T]]
[[Category: Mayerhofer H]]
[[Category: Meyer H]]
[[Category: Mueller-Dieckmann J]]
[[Category: Sattler M]]
[[Category: Schramm G]]
[[Category: Tripsianes K]]