View source for 4elz


==CCDBVFI:GYRA14VFI==
<StructureSection load='4elz' size='340' side='right'caption='[[4elz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4elz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliivibrio_fischeri_ES114 Aliivibrio fischeri ES114] and [https://en.wikipedia.org/wiki/Aliivibrio_fischeri_MJ11 Aliivibrio fischeri MJ11]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kua 3kua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ELZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elz OCA], [https://pdbe.org/4elz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elz RCSB], [https://www.ebi.ac.uk/pdbsum/4elz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5E5J7_ALIF1 Q5E5J7_ALIF1] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]

==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
__TOC__
</StructureSection>
[[Category: Aliivibrio fischeri ES114]]
[[Category: Aliivibrio fischeri MJ11]]
[[Category: Large Structures]]
[[Category: Buts L]]
[[Category: De Greve H]]
[[Category: De Jonge N]]
[[Category: Garcia-Pino A]]
[[Category: Haesaerts S]]
[[Category: Lah J]]
[[Category: Loris R]]
[[Category: Roelants K]]
[[Category: Simic M]]
[[Category: Sterckx Y]]