View source for 4er8


==Structure of the REP associates tyrosine transposase bound to a REP hairpin==
<StructureSection load='4er8' size='340' side='right'caption='[[4er8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4er8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er8 OCA], [https://pdbe.org/4er8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er8 RCSB], [https://www.ebi.ac.uk/pdbsum/4er8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAYT_ECOLI RAYT_ECOLI] Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosaic elements (BIMEs). RayT catalyzes cleavage and recombination of BIMEs. Binds REP sequences and cleaves BIMEs both upstream and downstream of the REP sequence. Could be important in the creation of BIME variability and amplification.<ref>PMID:20085626</ref> <ref>PMID:22199259</ref> <ref>PMID:22885300</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Chandler M]]
[[Category: Dyda F]]
[[Category: Ghirlando R]]
[[Category: Hickman AB]]
[[Category: Messing SAJ]]
[[Category: Ton-Hoang B]]