View source for 4ewi


==Crystal structure of the NLRP4 Pyrin domain==
<StructureSection load='4ewi' size='340' side='right'caption='[[4ewi]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ewi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewi OCA], [https://pdbe.org/4ewi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewi RCSB], [https://www.ebi.ac.uk/pdbsum/4ewi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NALP4_HUMAN NALP4_HUMAN] May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.<ref>PMID:12093792</ref> <ref>PMID:22388039</ref> 

==See Also==
*[[Pyrin domain|Pyrin domain]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Diederichs K]]
[[Category: Eibl C]]
[[Category: Hessenberger M]]
[[Category: Page R]]
[[Category: Peti W]]
[[Category: Puehringer S]]