View source for 4eza


==Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2==
<StructureSection load='4eza' size='340' side='right'caption='[[4eza]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4eza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eza OCA], [https://pdbe.org/4eza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eza RCSB], [https://www.ebi.ac.uk/pdbsum/4eza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eza ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Agacan M]]
[[Category: Arrowsmith CH]]
[[Category: Batty IH]]
[[Category: Bochkarev A]]
[[Category: Bountra C]]
[[Category: Crombet L]]
[[Category: Dixon MJ]]
[[Category: Downes CP]]
[[Category: Edwards AM]]
[[Category: Gray A]]
[[Category: Leslie NR]]
[[Category: Nedyalkova L]]
[[Category: Park H]]
[[Category: Schenning M]]
[[Category: Tempel W]]
[[Category: Tong Y]]
[[Category: Van Aalten DMF]]
[[Category: Weigelt J]]
[[Category: Zhong N]]