View source for 4ezc


==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==
<StructureSection load='4ezc' size='340' side='right'caption='[[4ezc]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [https://pdbe.org/4ezc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [https://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref> 

==See Also==
*[[Urea transporter|Urea transporter]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Cao Y]]
[[Category: Levin EJ]]
[[Category: Zhou M]]