View source for 4feq


==Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)==
<StructureSection load='4feq' size='340' side='right'caption='[[4feq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4feq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T8:4-(CYCLOPENTYLAMINO)-N-[3-(2-OXOPYRROLIDIN-1-YL)PROPYL]-2-{[2-(PYRIDIN-4-YL)ETHYL]AMINO}PYRIMIDINE-5-CARBOXAMIDE'>0T8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4feq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4feq OCA], [https://pdbe.org/4feq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4feq RCSB], [https://www.ebi.ac.uk/pdbsum/4feq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4feq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYRO3_MOUSE TYRO3_MOUSE] Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.<ref>PMID:15650770</ref> <ref>PMID:20363878</ref> <ref>PMID:21084607</ref> <ref>PMID:21291561</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kohrt JT]]
[[Category: Ohren JF]]
[[Category: Perrin LA]]
[[Category: Powell NA]]