View source for 4fog


==Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid==
<StructureSection load='4fog' size='340' side='right'caption='[[4fog]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fog]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FOG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fog OCA], [https://pdbe.org/4fog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fog RCSB], [https://www.ebi.ac.uk/pdbsum/4fog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fog ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bruning JB]]
[[Category: Harshbarger W]]
[[Category: Reddy MCM]]
[[Category: Sacchettini JC]]