View source for 4fsf


==Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14==
<StructureSection load='4fsf' size='340' side='right'caption='[[4fsf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FSF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0W0:(4R,5S,8Z)-8-(2-AMINO-1,3-THIAZOL-4-YL)-1-[3-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-1,2-OXAZOL-5-YL]-5-FORMYL-11,11-DIMETHYL-1,7-DIOXO-4-(SULFOAMINO)-10-OXA-2,6,9-TRIAZADODEC-8-EN-12-OIC+ACID'>0W0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fsf OCA], [https://pdbe.org/4fsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fsf RCSB], [https://www.ebi.ac.uk/pdbsum/4fsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fsf ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.,Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, Lall MS, Megan Lemmon M, Li C, Lin J, McCurdy SP, Mueller JP, Mullins L, Niosi M, Noe MC, Pattavina D, Penzien J, Plummer MS, Risley H, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Winton J, Young JA Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. Epub 2012 Jul 20. PMID:22892121<ref>PMID:22892121</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4fsf" style="background-color:#fffaf0;"></div>

==See Also==
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Han S]]