View source for 4fw1


==Crystal structure of two-domain RSV INTEGRASE covalently linked with DNA==
<StructureSection load='4fw1' size='340' side='right'caption='[[4fw1]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_Prague_C Rous sarcoma virus - Prague C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FW1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fw1 OCA], [https://pdbe.org/4fw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4fw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fw1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POL_RSVP POL_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).

==See Also==
*[[Integrase|Integrase]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rous sarcoma virus - Prague C]]
[[Category: Aihara H]]
[[Category: Shi K]]