View source for 4fzi


==Crystal structure of prostaglandin F synthase from Trypanosoma cruzi==
<StructureSection load='4fzi' size='340' side='right'caption='[[4fzi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzi OCA], [https://pdbe.org/4fzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzi RCSB], [https://www.ebi.ac.uk/pdbsum/4fzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PGFS_TRYCC PGFS_TRYCC] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde (By similarity).

==See Also==
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma cruzi strain CL Brener]]