View source for 4gfu


==PTPN18 in complex with HER2-pY1248 phosphor-peptides==
<StructureSection load='4gfu' size='340' side='right'caption='[[4gfu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfu OCA], [https://pdbe.org/4gfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfu RCSB], [https://www.ebi.ac.uk/pdbsum/4gfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

==See Also==
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Du YJ]]
[[Category: Sun JP]]
[[Category: Wang HM]]
[[Category: Yang DX]]
[[Category: Yang F]]
[[Category: Yu X]]
[[Category: Zhang Y]]