View source for 4gif


==C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L)==
<StructureSection load='4gif' size='340' side='right'caption='[[4gif]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GIF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gif OCA], [https://pdbe.org/4gif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gif RCSB], [https://www.ebi.ac.uk/pdbsum/4gif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gif ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PK2L1_HUMAN PK2L1_HUMAN] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.<ref>PMID:10517637</ref> <ref>PMID:19812697</ref> <ref>PMID:23212381</ref> <ref>PMID:24336289</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dobbins S]]
[[Category: Isacoff EY]]
[[Category: Li M-H]]
[[Category: Tong L]]
[[Category: Ulbrich MH]]
[[Category: Yang J]]
[[Category: Yu Y]]
[[Category: Zhang WK]]