View source for 4gme


==Crystal structure of mannonate dehydratase (target EFI-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate==
<StructureSection load='4gme' size='340' side='right'caption='[[4gme]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides_CB15 Caulobacter vibrioides CB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GME FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CS2:D-MANNONIC+ACID'>CS2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gme OCA], [https://pdbe.org/4gme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gme RCSB], [https://www.ebi.ac.uk/pdbsum/4gme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gme ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAND2_CAUVC MAND2_CAUVC] Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro).<ref>PMID:24697546</ref> 

==See Also==
*[[Mandelate racemase/muconate lactonizing enzyme 3D structures|Mandelate racemase/muconate lactonizing enzyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caulobacter vibrioides CB15]]
[[Category: Large Structures]]
[[Category: Almo SC]]
[[Category: Bhosle R]]
[[Category: Chowdhury S]]
[[Category: Evans B]]
[[Category: Gerlt JA]]
[[Category: Hammonds J]]
[[Category: Hillerich B]]
[[Category: Imker HJ]]
[[Category: Patskovsky Y]]
[[Category: Scott Glenn A]]
[[Category: Seidel RD]]
[[Category: Toro R]]
[[Category: Washington E]]
[[Category: Zencheck WD]]