View source for 4gnt


==Complex of ChREBP and 14-3-3beta==
<StructureSection load='4gnt' size='340' side='right'caption='[[4gnt]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gnt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GNT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnt OCA], [https://pdbe.org/4gnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gnt RCSB], [https://www.ebi.ac.uk/pdbsum/4gnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433B_MOUSE 1433B_MOUSE] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity).

==See Also==
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Huang N]]
[[Category: Zhang H]]