View source for 4goo


==Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Benzothiophene Aza-SAM==
<StructureSection load='4goo' size='340' side='right'caption='[[4goo]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4goo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GOO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Y2:5-{[(3S)-3-AMINO-3-CARBOXYPROPYL][2-(1-BENZOTHIOPHEN-3-YL)ETHYL]AMINO}-5-DEOXYADENOSINE'>0Y2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4goo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4goo OCA], [https://pdbe.org/4goo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4goo RCSB], [https://www.ebi.ac.uk/pdbsum/4goo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4goo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.

==See Also==
*[[DNA adenine methylase|DNA adenine methylase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Harmer JE]]
[[Category: Roach PL]]