View source for 4gzr


==Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP (Rv2346c-Rv2347c) complex in space group C2221==
<StructureSection load='4gzr' size='340' side='right'caption='[[4gzr]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gzr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.553&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzr OCA], [https://pdbe.org/4gzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzr RCSB], [https://www.ebi.ac.uk/pdbsum/4gzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESXO_MYCTU ESXO_MYCTU] Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages.<ref>PMID:26786654</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ahn CJ]]
[[Category: Arbing MA]]
[[Category: Chan S]]
[[Category: Eisenberg D]]
[[Category: Harris L]]
[[Category: He Q]]
[[Category: Kuo E]]
[[Category: Zhou TT]]