View source for 4h63


==Structure of the Schizosaccharomyces pombe Mediator head module==
<StructureSection load='4h63' size='340' side='right'caption='[[4h63]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4h63]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H63 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h63 OCA], [https://pdbe.org/4h63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h63 RCSB], [https://www.ebi.ac.uk/pdbsum/4h63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h63 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MED8_SCHPO MED8_SCHPO] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Cramer P]]
[[Category: Kurth F]]
[[Category: Lariviere L]]
[[Category: Plaschka C]]
[[Category: Seizl M]]
[[Category: Wenzeck L]]