View source for 4hcr


==Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659==
<StructureSection load='4hcr' size='340' side='right'caption='[[4hcr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hcr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HCR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hcr OCA], [https://pdbe.org/4hcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hcr RCSB], [https://www.ebi.ac.uk/pdbsum/4hcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hcr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Springer T]]
[[Category: Yu Y]]
[[Category: Zhu J]]