View source for 4hjb


==GCN4pLI derivative with alpha/beta/cyclic-gamma amino acid substitution pattern==
<StructureSection load='4hjb' size='340' side='right'caption='[[4hjb]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hjb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GM8:(2S)-2-[(1S,2S)-2-AMINOCYCLOHEXYL]BUTANOIC+ACID'>GM8</scene>, <scene name='pdbligand=XPC:(3S,4R)-4-AMINOPYRROLIDINE-3-CARBOXYLIC+ACID'>XPC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjb OCA], [https://pdbe.org/4hjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjb RCSB], [https://www.ebi.ac.uk/pdbsum/4hjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjb ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cyclic constraints have proven to be very effective for preorganizing beta-amino acid residues and thereby stabilizing beta- and alpha/beta-peptide helices, but little is known about possible preorganization effects among gamma residues. Here we assess and compare the impact of cyclic preorganization of beta and gamma residues in the context of a specific alpha/beta/gamma-peptide helix. The results show that beta residue preorganization is critical for helix stability but that gamma residue preorganization is less important.

Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water.,Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH J Am Chem Soc. 2013 May 23. PMID:23701135<ref>PMID:23701135</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hjb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Forest KT]]
[[Category: Gellman SH]]
[[Category: Mortenson DE]]
[[Category: Satyshur KA]]
[[Category: Shin YH]]