View source for 4hni


==crystal structure of ck1e in complex with PF4800567==
<StructureSection load='4hni' size='340' side='right'caption='[[4hni]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16W:3-[(3-CHLOROPHENOXY)METHYL]-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>16W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hni OCA], [https://pdbe.org/4hni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hni RCSB], [https://www.ebi.ac.uk/pdbsum/4hni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hni ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KC1E_HUMAN KC1E_HUMAN] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.<ref>PMID:12556519</ref> <ref>PMID:15070676</ref> <ref>PMID:15917222</ref> <ref>PMID:16790549</ref> 

==See Also==
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang X]]
[[Category: Long AM]]
[[Category: Zhao H]]