View source for 4hob


==The crystal structure of the Zalpha domain from Cyprinid Herpes virus 3==
<StructureSection load='4hob' size='340' side='right'caption='[[4hob]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hob]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyprinid_herpesvirus_3 Cyprinid herpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hob OCA], [https://pdbe.org/4hob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hob RCSB], [https://www.ebi.ac.uk/pdbsum/4hob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hob ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A4FTK7_9VIRU A4FTK7_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Zalpha domains are a subfamily of the winged helix-turn-helix domains sharing the unique ability to recognize CpG repeats in the left-handed Z-DNA conformation. In vertebrates, domains of this family are found exclusively in proteins that detect foreign nucleic acids and activate components of the antiviral interferon response. Moreover, poxviruses encode the Zalpha domain-containing protein E3L, a well-studied and potent inhibitor of interferon response. Here we describe a herpesvirus Zalpha-domain-containing protein (ORF112) from cyprinid herpesvirus 3. We demonstrate that ORF112 also binds CpG repeats in the left-handed conformation, and moreover, its structure at 1.75 A reveals the Zalpha fold found in ADAR1, DAI, PKZ, and E3L. Unlike other Zalpha domains, however, ORF112 forms a dimer through a unique domain-swapping mechanism. Thus, ORF112 may be considered a new member of the Z-domain family having DNA binding properties similar to those of the poxvirus E3L inhibitor of interferon response.

Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3.,Tome AR, Kus K, Correia S, Paulo LM, Zacarias S, de Rosa M, Figueiredo D, Parkhouse RM, Athanasiadis A J Virol. 2013 Apr;87(7):3998-4004. doi: 10.1128/JVI.03116-12. Epub 2013 Jan 30. PMID:23365431<ref>PMID:23365431</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hob" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cyprinid herpesvirus 3]]
[[Category: Large Structures]]
[[Category: Athanasiadis A]]
[[Category: Figueiredo D]]
[[Category: Kus K]]
[[Category: Paulo LM]]
[[Category: Tome AR]]
[[Category: De Rosa M]]