View source for 4htf


==Crystal structure of S-adenosylmethionine-dependent methyltransferase from Escherichia coli in complex with S-adenosylmethionine.==
<StructureSection load='4htf' size='340' side='right'caption='[[4htf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4htf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htf OCA], [https://pdbe.org/4htf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htf RCSB], [https://www.ebi.ac.uk/pdbsum/4htf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CMOM_ECO57 CMOM_ECO57] Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.[HAMAP-Rule:MF_02057]
__TOC__
</StructureSection>
[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Anderson WF]]
[[Category: Filippova EV]]
[[Category: Jedrzejczak R]]
[[Category: Joachimiak A]]
[[Category: Kiryukhina O]]
[[Category: Minasov G]]
[[Category: Shuvalova L]]