View source for 4htv


==Mouse importin alpha: BFDV Cap NLS peptide complex==
<StructureSection load='4htv' size='340' side='right'caption='[[4htv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4htv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Beak_and_feather_disease_virus Beak and feather disease virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htv OCA], [https://pdbe.org/4htv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htv RCSB], [https://www.ebi.ac.uk/pdbsum/4htv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

==See Also==
*[[Importin 3D structures|Importin 3D structures]]
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</StructureSection>
[[Category: Beak and feather disease virus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Forwood JK]]
[[Category: Patterson EI]]
[[Category: Raidal SR]]