View source for 4hxw


==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
<StructureSection load='4hxw' size='340' side='right'caption='[[4hxw]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1A0:(3R)-1-[5-CHLORO-6-ETHYL-2-(PYRIDO[2,3-B]PYRAZIN-7-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]PYRROLIDIN-3-AMINE'>1A0</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hxw OCA], [https://pdbe.org/4hxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hxw RCSB], [https://www.ebi.ac.uk/pdbsum/4hxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hxw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA] 

==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
__TOC__
</StructureSection>
[[Category: Enterococcus faecalis V583]]
[[Category: Large Structures]]
[[Category: Bensen DC]]
[[Category: Tari LW]]
[[Category: Trzoss M]]